Endocrine Abstracts

Introduction: Primary hyperparathyroidism (PHPT) clinic occurs when the parathyroid glands secrete excess parathormone (PTH) due to hyperplasia, adenomatous or carcinomatous change. In the pathogenesis of the disease, dysregulation has been observed in extracellular signal-regulated 1/2 (ERK 1/2) pathways from the mitogen activated protein kinase (MAPK) family, c-Jun N-terminal kinase (JNK) pathways, and phosphatidylinositol-3 kinase (PI3K) pathways. Progranulin (PGRN) is a gl...